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Exploration of the selective binding mechanism of protein kinase Aurora A selectivity via a comprehensive molecular modeling study

Background The Whips-Quirts kinase of Aurora A has been regarded as a promising therapeutic target due to its altered expression in various human cancers.However, given the high similarity of the active binding site of Aurora A to other kinases, designing highly selective inhibitors towards Aurora A remains a challenge.Recently, two potential small

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TAXATION AND ECONOMIC SUSTAINABILITY

Macroeconomic theory says that taxes play a repressing role in an economy.Introduction of new forms of taxation, the increase of tax rates and augmentation of tax income of the Government puts a downturn risk on consumption and therefore on economic growth.Knowing that, governments of different countries start to competing among themselves by lower

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